No. 1 Purdue is a 10.5-point home favorite over Penn State on Wednesday in a Big Ten game Purdue is on an eight-game winning streak A look at the Penn State vs Purdue matchup and odds can be found below with a pick No. 1 Purdue will try to keep its hot streak going when it hosts Penn State at 6:30 p.m. ET Wednesday in a Big Ten game at Mackey Arena in West Lafayette, Ind. Purdue (21-1, 10-1 home, 10-1 Big Ten) is on an eight-game winning streak after defeating Michigan State 77-61 on Sunday. Penn State (14-7, 1-4 road, 5-5 Big Ten) beat Michigan 83-61 on Sunday and has won three of its last five games while matching last season’s win total. The game will be broadcast on the Big Ten Network. Penn State vs Purdue Odds Team Moneyline Spread Total Penn State +410 +10.5 (-110) Over 135 (-110) Purdue -570 -10.5 (-110) Under 135 (-110) Odds as of January 31st at DraftKings. Get this week’s DraftKings Sportsbook bonus code . Purdue is a 10.5-point favorite