We’ve made our San Francisco 49ers vs Buffalo Bills prediction for Sunday Night Football in Week 13 The latest SF vs BUF odds favor the Bills by 6 points at home Read below for 49ers vs Bills prediction, odds and expert picks The San Francisco 49ers (5-6) visit the red-hot Buffalo Bills (9-2) on Sunday Night Football in a Week 13 clash between early Super Bowl favorites now heading in opposite directions. The Bills have won six straight, including an impressive 30-21 victory over Patrick Mahomes and the Chiefs before their Week 12 bye. Meanwhile, the injury-plagued Niners are reeling from back-to-back losses, mustering just 10 points in a 38-10 defeat at Green Bay — their worst loss under Kyle Shanahan. Here’s our 49ers vs Bills prediction and the latest odds for Sunday Night Football. San Francisco 49ers vs Buffalo Bills Odds Team Spread Moneyline Total 49ers +6 (-110) +220 Over 44.5 (-110) Bills -6 (-110) -270 Under 44.5 (-110) The San Francisco 49...