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A.I. NFL Picks for Every Week 1 Game

  • SportRadar’s A.I. has analyzed every NFL Week 1 game and set out its ATS and O/U picks for all 16 games
  • Overall, our A.I. picks like the under to hi in 12 of 16 games
  • Below, see our A.I. NFL picks for every Week 1 game

It’s a brave new world for NFL bettors, one in which certain people (myself included) can ask sophisticated A.I. models to analyze matchups and provide best bets. That’s exactly what I have done using the internal A.I. from SportRadar, SBD’s parent company.

Below, I have set out our A.I.’s picks against the spread and O/U predictions for all 16 games on the Week 1 schedule.

A.I. NFL Picks for Week 1

Game ATS Pick O/U Pick
Cowboys vs Eagles PHI -7 Over 46.5
Chiefs vs Chargers KC -3.5 Under 45.5
Buccaneers vs Falcons ATL +2.5 Under 47.5
Dolphins vs Colts IND -1.5 Over 46.5
Steelers vs Jets PIT -3 Under 38.5
Panthers vs Jaguars JAX -3 Over 46.5
Giants vs Commanders WSH -6 Under 45.5
Cardinals vs Saints ARI -6.5 Under 42.5
Bengals vs Browns CIN -6 Under 46.5
Raiders vs Patriots LV +2.5 Under 42.5
49ers vs Seahawks SEA +2.5 Under 44.5
Titans vs Broncos DEN -7.5 Under 41.5
Lions vs Packers DET +2.5 Over 46.5
Texans vs Rams HOU +2.5 Under 44.5
Ravens vs Bills BAL +0.5 Under 51.5
Vikings vs Bears CHI +1.5 Under 42.5

Picks generated on August 30, 2025. All odds from Draftkings. Claim the top football betting promo codes ahead of Week 1.

Bookmark SBD’s NFL odds page and NFL public betting splits to see up-to-the-minute lines and the betting trends for each game of the season.

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AI Picks for NFL Week 1 Skew Heavily to Unders

Unders are the most-pronounced trend in our AI picks for Week 1. The model likes the under in 12 of 16 games (75%), which includes targeting the under in the lowest total on the board: 38.5 in Steelers vs Jets, a number which opened at 41.5. The PIT/NYJ total was as low as 37.5 last week before some buy-back on the over.

Totals were split an even 8-8 in Week 1 of last season, but unders went a torrid 12-4 in Week 1 of the 2023 campaign.

AI NFL Picks Almost Evenly Split Between Favorites and Underdogs in Week 1

Our model isn’t showing a particular bias towards favorites or underdogs in Week 1. The 16 ATS picks include nine favorites to cover and seven underdogs.

It is, however, showing a potential bias towards big favorites. Five Week 1 spreads are sitting at six points or higher: Eagles (-7) vs Cowboys, Commanders (-6) vs Giants, Bengals (-6) at Browns, Broncos (-7.5) vs Titans, and Cardinals (-6.5) at Saints. Our AI model likes the favorite to cover in all five.

Last year, favorites of six points or more went just 0-2-1. In 2023, they went 1-1, though that drops to 1-3 when you include five-point spreads.

So, here, our AI model is very much going against recent Week 1 trends.

Home Teams and Road Teams on Equal Footing in A.I. Picks for NFL Week 1

Notably, our A.I. NFL picks are evenly split between home teams and road teams, with our A.I. model taking eight home squads and eight visiting teams to cover the spread in NFL Week 1.

Home teams were an impressive 9-6 ATS last year (excluding the Packers/Eagles game in São Paulo, Brazil), but an abysmal 4-12 ATS in Week 1 of 2023.

Note that the Chiefs/Chargers matchup in Week 1 of this season will also take place in São Paulo.

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The post A.I. NFL Picks for Every Week 1 Game appeared first on Sports Betting Dime.



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