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A.I. NFL Picks for Week 5 – ATS and O/U A.I. Predictions for Every Game

  • I have generated A.I. picks for all 14 NFL games on the Week 5 slate
  • Our A.I. model continues to lean towards unders despite a poor O/U record this season
  • Below, see A.I. NFL picks for all Week 5 games, including ATS and O/U predictions

Nearly a quarter of the way through the 2025 NFL regular season, our A.I. continues to struggle with its predictions. It is, however, coming off its most successful week of the season (maybe least unsuccessful would be more accurate). Perhaps with another week of data to work with, Week 5 will set a new benchmark.

In the table below, I have set out our A.I.’s NFL picks for Week 5, including its ATS and O/U prediction for all 14 games (four teams – ATL, CHI, GB, PIT – are on bye).

A.I. NFL Picks for Week 5

Game ATS Pick O/U Pick
SF 49ers vs LA Rams 49ers +4.5 Under 46.5
MIN Vikings vs CLE Browns Vikings -3.5 Under 36.5
LV Raiders vs IND Colts Colts -6.5 Over 48.5
NY Giants vs NO Saints Saints +1.5 Under 41.5
DAL Cowboys vs NY Jets Cowboys -2.5 Over 47.5
DEN Broncos vs PHI Eagles Eagles -4.5 Under 44.5
MIA Dolphins vs CAR Panthers Panthers +1.5 Over 44.5
HOU Texans vs BAL Ravens Texans +4.5 Under 43.5
TEN Titans vs ARI Cardinals Cardinals -9.5 Under 41.5
TB Buccaneers vs SEA Seahawks Seahawks -3.0 Under 44.5
DET Lions vs CIN Bengals Lions -8.5 Over 49.5
WSH Commanders vs LA Chargers Commanders +3.0 Under 47.5
NE Patriots vs BUF Bills Patriots +8.5 Under 49.5
KC Chiefs vs JAX Jaguars Jaguars +3.0 Under 45.5

Week 4 was the best of the season so far for our A.I.’s picks, but that’s not saying much. The A.I.’s best bets were 6-8 against the spread and 7-7 over/under in Week 4 heading into the MNF doubleheader, where it has Jets +2.5 and under 45.5 in the first game, and Bengals +7.5 and under 44.5 in the second.

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Our A.I. remains well below .500 on both its ATS and O/U picks almost a quarter of the way through the season.

A.I. Picks Record 2025 Regular Season:

  • ATS: 20-28
  • O/U: 18-30

Readers can bookmark SBD’s NFL odds page to see up-to-the-minute lines for every game this year, both regular season and playoffs.

NFL Week 5 A.I. Picks Still Love Unders

The NFL Week 5 A.I. picks lean heavily towards unders, which it has every week this season. The Week 5 O/U picks include ten under bets and just four over bets.

The only overs it is betting in Week 5 are: Raiders vs Colts (over 48.5), Cowboys vs Jets (over 47.5), Dolphins vs Panthers (over 44.5), and Lions vs Bengals (over 49.5).

The A.I. had hit just two of its 11 over wagers heading into Week 4, but went 3-1 on over bets on Sunday in Week 4, hitting on:

  • Eagles vs Buccaneers – Over 45.5
  • Ravens vs Chiefs – Over 48.5
  • Packers vs Cowboys – Over 48.5

Click the links below if you want to tail the A.I.’s over bets in Week 5.

A.I. NFL Picks for Week 5 Evenly Split Between Favorites and Underdogs

Our A.I. picks in the first four weeks leaned towards favorites each time. Week 5 marks the first time that it has picked just as many underdogs to cover the spread as chalk.

That perhaps makes some internal sense since the A.I. had its best week picking underdogs in Week 4, going 3-2 ATS. It was just 5-14 ATS picking underdogs in the first three weeks of the season.

The underdogs our A.I. is picking in Week 5 are:

  • 49ers +4.5 (@ Rams)
  • Saints +1.5 (vs Giants)
  • Panthers +1.5 (vs Dolphins)
  • Texans +4.5 (@ Ravens)
  • Commanders +3.0 (@ Chargers)
  • Patriots +8.5 (@ Bills)
  • Jaguars +3.0 (vs Chiefs)

Click on the links below to tail of our A.I.’s Week 5 underdog picks that are still available at their opening lines.

The post A.I. NFL Picks for Week 5 – ATS and O/U A.I. Predictions for Every Game appeared first on Sports Betting Dime.



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