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Blue Devils Favored in Duke vs St John’s Opening Odds

  • #1 Duke will face #5 St John’s in the East Region Sweet 16
  • Despite ongoing injury issues, Duke has opened as the betting favorite
  • See the opening Duke vs St John’s odds (spread, moneyline, and game total)

A heavyweight clash is on tap in the East Region Sweet 16 as the #1 Duke Blue Devils (34-2 SU, 20-16 ATS) face the #5 St John’s Red Storm (30-6 SU, 22-12-1 ATS) on Friday, March 27th, at Capital One Arena in Washington, DC.

Tip-off time is still TBD. What is known is the opening Duke vs St John’s odds, and they heavily favor the ACC champs.

St John’s vs Duke Opening Odds

Team Spread ML Total
St John’s +6.5 (-110) +210 O 141.5 (-110)
Duke -6.5 (-110) -258 U 141.5 (-110)

The Blue Devils have opened as 6.5-point ATS favorites and -258 on the moneyline. The Red Storm come back as +210 underdogs.

The total is sitting at 141.5 with -110 odds on both the over and the under. The teams are a combined 0-4 O/U in the tournament so far.

Odds as of March 22nd at DraftKings. See where to legally bet in the US.

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  • BETMGM SPORTSBOOK T&Cs: Gambling problem? Call 1-800-GAMBLER (Available in the US), Call 877-8-HOPENY or text HOPENY (467369) (NY), Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

Duke started the tournament as the favorite in the March Madness championship odds but have faded to third. The Blue Devils are currently trading at 19¢ at prediction site Kalshi, which is the equivalent of +426 odds.

St John’s is trading at 4¢ to win its first national title, equal to +2400 odds.

After surviving a huge scare from #16 Siena in the first round, Duke made short work of #9 TCU in the round of 32 (81-58). Cameron Boozer, the favorite in the Wooden Award odds, had a game-high 19 points and 11 rebounds. He was highly efficient, shooting 7-of-10 from the field and 5-of-5 from the stripe while also generating three steals.

St John’s followed up its 79-53 rout of #12 Northern Iowa with a 67-65 buzzer-beater victory over #5 Kansas. Big East Player of the Year Zuby Ejiofor is averaging a double-double in the tournament: 16 points and 10 rebounds.

Dylan Darling’s only two points of the game came on the winning bucket as time expired.

There is no relevant history between the teams. Duke and St John’s haven’t played since 2019.

Duke vs St John’s Team Stats

Duke Stat St John’s
36.0 GP 35.0
2nd KenPom Rank 14th
81.9 PPG 81.5
63.1 OPP PPG 69.5
48.9 FG% 45.4
34.6 3P% 33.3
73.2 FT% 72.6
40.4 RPG 38.8
10.9 ORPG 10.9
26.6 DRPG 24.0
16.8 APG 16.2
7.6 SPG 7.8
3.3 BPG 4.9
10.3 TOPG 10.0
8.9 3PM/G 7.0
25.8 3PA/G 21.0

The stats in the table include regular season, conference tournaments, and the NCAA Tournament.

Bookmark SBD’s college basketball odds to see up-to-the-minute lines for every game of March Madness.

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  • DRAFTKINGS T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-522-4700, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 4/6/26 at 11:59 PM ET. Sponsored by DK.

  • BET365 SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/MO/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ only (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/MO/NC/NJ/OH/PA/TN/VA

  • BETMGM SPORTSBOOK T&Cs: Gambling problem? Call 1-800-GAMBLER (Available in the US), Call 877-8-HOPENY or text HOPENY (467369) (NY), Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

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