The NFL season accelerates into mid-October and sportsbooks have already released opening lines for a pivotal Week 7 slate.
Between an international spectacle at Stade de France featuring New Orleans and Pittsburgh, a ferocious Sunday Night Football duel at Lumen Field pitting Seattle against Patrick Mahomes and the Kansas City Chiefs, and an NFC East grudge match on Monday Night Football between Philadelphia and Dallas, Week 7 delivers an electric betting board from Thursday night through Monday evening.
The table below lists the opening NFL Week 7 odds, including spread, total, and moneyline for all 14 games. The Buffalo Bills, Jacksonville Jaguars, Los Angeles Chargers, and Washington Commanders are on bye.
NFL Week 7 Odds
Odds as of Oct 18 at DraftKings. Check out the best NFL betting promos ahead of Week 7.
The 49ers have surged to the top of the Super Bowl odds at +650 after Week 6 (or rather, all of Week 6 except San Fran’s MNF tilt with Washington). The Niners are narrowly ahead of the division rival Rams at +700, while the Bills (+750), Ravens (+800), and Chiefs (+900) round out the top five favorite for the 2027 Lombardi Trophy.
Opening Patriots vs Bears Odds
Week 7 action kicks off at Soldier Field on Thursday night; the Chicago Bears (4-2, 4-2 ATS, 3-3 O/U) have opened as 2.5-point home favorites (-115) over the New England Patriots (4-2, 4-2 ATS, 3-3 O/U). Both squads enter following Week 6 victories – Chicago defeated Atlanta 31-23 on the road, while New England topped the Jets 26-19 at home.
DraftKings has Chicago at -142 on the moneyline (58.7% implied win probability), with New England returning at +120 (45.5% implied win probability).
The total opened at 49.5 points (-110 both sides). Chicago averages 25.0 PPG behind Caleb Williams, featuring high-flying shootouts against Carolina (96 combined points) and Atlanta (54). New England rides a three-game winning streak, scoring 29, 45, and 26 points while allowing just 18.8 PPG defensively. With both defenses allowing under 20.0 PPG, oddsmakers will test whether these offenses can sustain their mid-season scoring spikes under the primetime lights.
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Opening Steelers vs Saints Odds
Sunday’s international clash heads to Stade de France in Saint-Denis, where the Pittsburgh Steelers (4-2, 4-2 ATS, 4-2 O/U) are listed as 2.5-point neutral-site favorites (-110) over the New Orleans Saints (2-4, 3-3 ATS, 5-1 O/U). On the moneyline, Pittsburgh sits at -142 (58.7% implied win probability) with New Orleans priced at +120 (45.5% implied win probability).
Pittsburgh enters off a 26-19 overtime win against Tampa Bay, while New Orleans snapped a four-game skid by outscoring the Giants 34-27.
The total opened at 44.5 points (-110 both sides). The over has been New Orleans’ dominant trend, hitting in five of six games (61, 41, 62, 69, 36, and 61 total points). The Saints score 25.3 PPG but surrender 29.7 PPG. Pittsburgh has scored 26 or more points in three of their last four games while allowing 21.3 PPG.
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Opening Giants vs Texans Odds
Sunday morning in Houston features the slate’s widest spread, as the Houston Texans (2-4, 3-3 ATS, 4-2 O/U) open as 9.5-point home favorites (-110) over the New York Giants (3-2-1, 3-3 ATS, 4-2 O/U).
Houston at -470 on the moneyline (82.5% implied win probability), with New York returning as a heavy +360 road underdog (21.7% implied win probability).
The total opened at 42.5 points (-110 both sides). Overs have cashed in four of Houston’s six games, with C.J. Stroud’s offense averaging 24.0 PPG and participating in shootouts of 67, 64, and 65 points. New York is also 4-2 to the over, with their past three games totaling 60, 54, and 61 points. Despite both defenses surrendering over 23.0 PPG, oddsmakers project Houston to dictate a controlled game script that caps total scoring.
Houston has won two straight after beating Jacksonville 34-31 in London, whereas the Giants fell short in a comeback bid at home against New Orleans (34-27).
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Opening Bengals vs Ravens Odds
An AFC North duel headlines the early window, where the Baltimore Ravens (4-2, 4-2 ATS, 4-2 O/U) open as 3.5-point home favorites (+100) over the Cincinnati Bengals (3-2, 3-2 ATS, 3-2 O/U). Baltimore looks to rebound from a 13-10 loss in Cleveland, while Cincinnati enters fresh off their Week 6 bye.
DraftKings set Baltimore at -180 on the moneyline (64.3% implied win probability), with Cincinnati at +150 (40.0% implied win probability) and juiced to -120 at +3.5.
The total opened at 50.5 points (-110 both sides), tied for the highest early total. Joe Burrow’s offense generates 25.6 PPG, eclipsing 27 points in three of five games (including shootouts of 60 and 57 points). Baltimore averages 26.0 PPG, having surpassed 50 combined points in three games before a 13-10 slugfest with Cleveland in Week 5. But that came with Tyler Huntley under center and oddsmakers are pricing this game as if Lamar Jackson will be back in action after a two-week absence.
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Opening 49ers vs Falcons Odds
Also in the early Sunday window, the NFC-leading San Francisco 49ers (5-0, 4-1 ATS, 3-2 O/U) have opened as 4.5-point road favorites (-110) against the Atlanta Falcons (2-4, 2-4 ATS, 4-2 O/U). On the moneyline, San Francisco is a hefty -225 favorite (69.2% implied win probability) with Atlanta at +185 (35.1% implied win probability).
The total opened at 50.5 points (Over -115 / Under -105). San Francisco leads the NFC with 30.8 PPG, topping 30 points in three of five contests behind Brock Purdy. Atlanta is 4-2 to the over, averaging 23.7 PPG while surrendering 25.5 PPG. Facing San Francisco’s high-efficiency offense in a fast dome track, oddsmakers expect frequent chunk plays and steady scoring drives.
San Francisco plays on a short week after hosting Washington on Monday night, while Atlanta seeks to halt a two-game skid following a 31-23 loss to Chicago.
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Opening Buccaneers vs Panthers Odds
An NFC South battle takes over Bank of America Stadium, where the Carolina Panthers (3-2, 3-2 ATS, 3-2 O/U) open as 3-point home favorites (-120) over the Tampa Bay Buccaneers (1-5, 2-4 ATS, 2-4 O/U). Carolina enters after a 25-14 win in Philadelphia, while Tampa Bay dropped to the division basement with a 26-19 overtime loss to Pittsburgh.
DraftKings set Carolina at -180 on the moneyline (64.3% implied win probability), with Tampa Bay returning at +150 (40.0% implied win probability) and even-money (+100) at +3.
The total opened at 43.5 points (-110 both sides). Carolina has found offensive consistency under Dave Canales, averaging 29.2 PPG and surpassing 30 points in three of five games. Tampa Bay is 2-4 to the over, held back by an offense averaging just 19.8 PPG that has failed to hit 20 points in four of six outings. With Carolina controlling possession behind Chuba Hubbard and protecting the football, oddsmakers favor the home side in a tightly contested divisional clash.
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Opening Dolphins vs Jets Odds
Desperation meets divisional rancor at MetLife Stadium. New York (2-4, 2-4 ATS, 2-4 O/U) enters as a 3-point home favorite (-115) against the winless Miami Dolphins (0-5, 1-4 ATS, 1-4 O/U), with the Jets priced at -160 on the moneyline (61.5% implied probability) to Miami’s +135 dog tag.
What jumps out immediately is the rock-bottom 39.5-point total. Oddsmakers aren’t expecting fireworks between two offenses that have struggled to find any sustained rhythm. Miami is producing an NFL-low 14.0 points per game, failing to crack 20 points in four of five contests, while Jeff Hafley’s defense allows 26.4 points per game. Meanwhile, New York (18.7 PPG) has seen four of their six games land comfortably under 42 total points.
The Jets’ defense gives up just 20.3 points per contest, so if Aaron Rodgers and Breece Hall’s absence limit explosive chunk gains, this AFC East slugfest projects as a field-position grind where points come at a premium.
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Opening Packers vs Lions Odds
An explosive NFC North title eliminator headlines Ford Field, where oddsmakers opened Detroit as 3.5-point home favorites (-105) over Green Bay (+3.5, -115), with a sky-high 53.5-point total that currently leads the entire Week 7 board.
Few teams produce track meets quite like Dan Campbell’s Lions. Detroit (3-2, 3-2 ATS, 4-1 O/U) leads the league with 32.8 points per game, yet their secondary has been routinely torched, leaking 29.6 points per contest in wild shootouts against Buffalo (41-31), Carolina (32-26), and New Orleans (31-30).
Green Bay (3-2, 3-2 ATS, 2-3 O/U) counters with Jordan Love and an ascending offense that hung 31 points on Chicago in Week 5. The total of 53.5 demands at least seven combined touchdowns or heavy red-zone volume, but both offenses rank among the top ten in EPA per drive. With Detroit favored at -175 (63.6% implied) and Green Bay live at +145 (40.8%), expect heavy two-way action from traders anticipating an indoor fireworks display.
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Opening Chiefs vs Seahawks Odds
Lumen Field hosts Sunday Night Football, matching Patrick Mahomes and the Kansas City Chiefs against a Seattle Seahawks squad catching 3.5 points on their home deck:
- Moneyline Split: Kansas City -185 (64.9% Implied) | Seattle +155 (39.2% Implied)
- O/U Line: 45.5 Points (-110 Juice)
Kansas City’s market respect remains unmatched. The Chiefs are 4-0 straight up behind Steve Spagnuolo’s elite scoring defense, which yields just 16.6 points per game and hasn’t allowed more than 20 points since Week 2. Seattle (3-3, 2-3-1 ATS, 3-3 O/U) provides a unique test, however. Mike Macdonald’s group averages 24.7 points per game and has pushed past 50 combined points in shootouts against the Chargers and Commanders.
Seattle has dropped two of three at home, but catching more than a field goal at Lumen Field in a primetime environment is historically sharp territory. With Kansas City controlling pace through long, methodical drives (27.4 PPG) and Seattle relying on explosive perimeter shots to DK Metcalf and Jaxon Smith-Njigba, this 45.5 total balances Seattle’s volatility against Kansas City’s defensive chokehold.
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