View our expert Week 10 college football picks against the spread for Saturday (Nov. 2) We’re backing three underdogs, including South Carolina (+2.5) and Louisville (+10.5) Read below for expert Week 10 college football picks against the spread, plus key betting trends Another massive college football Saturday is on deck for Week 10, and I’ve identified three underdog plays that offer notable betting value. I’m back sharing my top college football against the spread picks for Saturday, November 2nd. For Week 10, I’m targeting an SEC home dog that thrives against ranked opponents, while also backing two road underdogs in challenging environments. The numbers and matchups suggest all three teams should keep things close. Let’s dive into my Week 10 college football picks against the spread, with detailed analysis and key trends for each selection. Week 10 CFB ATS Picks Matchup Pick (Odds) South Carolina vs Texas A&M South Carolina +2.5 (-110) UCLA vs Nebraska